Enhancing Surgical Performance...
... Optimising Ocular Protection

VISIOL® - a unique viscoelastic for cataract surgery

VISIOL® contains 2% sodium hyaluronate and mannitol.  


Cohesive & Dispersive

VISIOL® displays both cohesive and dispersive behaviours. An optimal viscosity of 60,000 mPas at zero shear rate has been reached with the right balance between sodium hyaluronate (SH) molecular weight (1.8 million Da) and concentration (2%). 

VISIOL® is adapted to all the different stages of the cataract surgery procedure:

- Space creation
- Capsulorhexis
- Phacoemulsification
- Lens implantation
- Aspiration



VISIOL® covers efficiently the anterior chamber tissues as well as instruments and IOL due to its low angle of contact.1


Low post-operative IOP

Intraocular pressure (IOP) increase is considered a major post-operative consequence in cataract surgery despite viscoelastic removal. A clinical trial has shown that VISIOL® did not cause clinically significant elevation of IOP1 (see the figure below).


Protective role of mannitol: free radical scavenging

VISIOL® is a unique viscoelastic that contains the special combination of sodium hyaluronate and mannitol, a linear sugar-alcohol. Mannitol demonstrated the ability to prevent rapid breakdown of sodium hyaluronate chains by scavenging reactive oxygen species (ROS) (fig.1).

Fig. 1: Mannitol reacts with ROS slowing down the degradation of the SH chains.

The phacoemulsification step can generate ROS3. Thanks to the mannitol contained in VISIOL®, the SH chains are protected against rapid depolymerisation. As a result, the product viscosity is maintained sufficiently high during the complete cataract surgery procedure until its removal (fig. 2). 

Fig. 2: Inhibitory effect of 30 mM of mannitol on SH degradation

VISIOL® is designed for the hand of the surgeon ...








Survey performed on 10 surgeons, data on file. 


... and for the eye of the patient

1 TRB Chemedica, data on file.

Overall, VISIOL® offers the optimum characteristics thoughout cataract surgery ...
... while providing good protection to the patient

  • Sodium hyaluronate 2%
  • Molecular weight: 1.8 million Da
  • Produced by bacterial fermentation
  • Cohesive & dispersive behaviours
  • Protective role of mannitol against rapid depolymerisation
  • Zero shear rate viscosity: 60,000 mPas
  • Volume of product: 1.0 ml
  • One glass syringe with Luer-Lok
  • Terminally steam sterilised
  • Storage conditions: 2-25º C
  • 3-year shelf life


Richard-Reitzner-Allee 1
85540 Haar/München, Germany

9 Evolution
Lymedale Business Park